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•As more people awaken to the dangers of vaccines, they discover a persistent problem vaccine safety advocates have faced for decades: talking to vaccine zealots is like speaking to a brick wall. •Regardless of the evidence presented, you cannot reach them—sometimes it feels like speaking to religious fanatics unwilling to consider the “blasphemy you’re spewing forth.”… |
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A new peer-reviewed paper, based on a review of 519 studies, challenges the long-standing belief that autism is primarily a neurological condition stemming from a genetic brain disorder.
The authors, who include Children’s Health Defense (CHD) Chief Scientific Officer Brian Hooker, concluded that autism may arise from a far more dynamic — and potentially modifiable — set of biological drivers.
Those drivers include immune system disruption, environmental exposures and gut-brain physiology.
Instead of trying to locate autism solely in the genes or inside the brain, the authors suggest examining the entire constellation of immune, neurological, gastrointestinal, metabolic, and environmental influences that shape human development.
They called for precision medicine: personalized interventions informed by each individual’s unique mix of exposures, immune markers, microbiome composition, metabolic patterns and genetic sensitivities.
This could include nutritional and metabolic therapies, microbiome interventions, anti-inflammatory strategies and mind-body approaches aimed at rebalancing the body’s regulatory networks.
The paper, published Dec. 20 in Molecular Neurobiology, covers decades of research across the fields of immunology, toxicology, neurobiology and environmental health.
Written for a broad audience, the paper explains how autism spectrum disorder (ASD) is driven by — and affects — multiple body systems, including the immune, digestive and central nervous systems.
“This paper solidifies the immunological aspects of the etiology of autism and refutes any past notion that the disorder does not stem from neuroimmune activation and autoimmunity,” Hooker said. “It’s time to throw away old notions based on the lies of vaccine profiteers.”
Martha Herbert, M.D., Ph.D., one of the paper’s authors, told The Defender in an interview last year that a “whole-body” approach is imperative to understanding complex chronic illnesses such as autism.
Over $1 billion in research — and still no autistic’ gene identified
For years, the dominant narrative around autism has centered on genetics. Autism Speaks, the Simons Foundation and similar organizations have in the past 10 year invested over $1 billion in the search for a genetic basis for the disease.
But after decades of effort, researchers have failed to identify a genetic driver that can explain the rising prevalence of autism or the significantly different ways the disorder manifests itself in individuals, the authors of the new study said.
Studies on pairs of twins and population data increasingly suggest that genetics tells only part of the story.
According to the new paper, most autism research has overlooked a key player: the immune system. The authors detail a large and growing body of evidence showing chronic neuroinflammation — including abnormal activity in the brain’s immune and support cells — in people with autism.
They describe studies documenting shifts in inflammatory cytokines, changes in T-cell and B-cell activity, and autoantibodies that target brain tissue. Some evidence also points to maternal immune activation during pregnancy as a potential trigger that can shape neurodevelopment long before birth.
Understanding these dynamics, they argue, “gives us a platform for not only examining the role of the immune system in the etiology, pathogenesis, and pathophysiology of ASD but also understanding social and higher-level processes of consciousness for individuals on the spectrum.”
The publication comes as federal health agencies have begun to investigate the environmental drivers of the disease, including vaccines.
Autism emerges from cumulative environmental pressures
Rather than describe autism as the result of a single trigger, the review frames the condition as emerging from the cumulative pressure of environmental stressors — everything from heavy metals and industrial chemicals to pesticides, medications used in pregnancy, electromagnetic radiation and endocrine-disrupting compounds.
These exposures can overwhelm the body’s ability to maintain “allostasis” — the neurobiological adaptive balancing act that keeps biological systems stable — the authors said.
When too many stressors hit at once, especially during critical windows of development, the body’s allostatic systems can be overworked, pushing them to a “tipping point.” The body may cross a threshold that affects immune regulation, metabolism and brain development. That stress can compromise the body’s detoxification process and fuel chronic disease.
The authors highlight the gut’s role in autism, pointing out that children with autism often experience gastrointestinal problems. Researchers have found that disruptions in the gut microbiome correlate with severity of behavioral symptoms.
They explain that immune cells, nerves, microbes and metabolites constantly communicate along the “gut-brain axis.” When this system is disturbed, the consequences can extend far beyond digestion, affecting neurotransmitter production, immune responses and the blood-brain barrier.
This broader physiological perspective leads the authors to challenge some of the field’s assumptions about the autistic brain.
Differences seen in the brains of people with autism in MRI scans and post-mortem studies may not all be congenital or fixed, the authors said. Instead, they could indicate the downstream effects of inflammation, oxidative stress or metabolic dysfunction — processes that, in principle, can change over time. MRIs may offer just a snapshot of a person’s changing biology.
Time for a shift from ‘magic bullet’ paradigm to precision medicine
Autism treatment has been shaped by a “magic bullet” medical paradigm that seeks to manage symptoms with single-target drugs rather than address underlying biological complexity, according to the authors.
“Novel therapeutics to address core symptoms of ASD have been largely ignored by mainstream medicine and are desperately needed,” said Hooker. “Potential treatments necessitate neuroimmunological perspectives and a ‘whole body’ approach, integrated with personalized and precision nutrition and mind-body modalities.”
They also acknowledge the strengths, abilities and individuality of autistic people. Their argument is not that autism is a disease to be “fixed,” but that the biological challenges many autistic individuals experience deserve deeper scientific attention — and that understanding those challenges may open doors to better support, improved quality of life, and more tailored interventions.
Their message is that autism is not a single story told by DNA, but a complex interplay of biology and environment—and that story may be far more dynamic than we once thought.
They conclude that:
“Only once we understand that ASD is not genetically inevitable or a genetic tragedy but an environmental and physiological catastrophe, will we truly be able to grasp and address the root causes of the dramatic rise in its prevalence. …
“The point henceforward becomes not just to support and seek full recovery for those diagnosed with ASD, but also how we as individuals, families, communities, and society in the contemporary era can most effectively protect future generations.”
Dr. Paul Thomas, a retired pediatrician who practiced for 35 years, spoke with CHD.TV Director Polly Tommey about questions many parents wrestle with: Do unvaccinated children get sick more often? When is hospital care really necessary? How should parents handle disease outbreaks, childhood fevers and family pressure to vaccinate?
Thomas, who no longer holds a medical license and now describes himself as a family coach, reflected on his career, his break from mainstream pediatrics and what he observed firsthand as more parents chose not to vaccinate.
Thomas said he walked away from conventional pediatrics after witnessing repeated vaccine injuries.
He recalled seeing “four kids in a row over four years regress into severe autism after vaccines,” an experience that changed his outlook permanently. “Once I saw vaccine injury, I couldn’t unsee it,” he said.
When Thomas stopped following the Centers for Disease Control and Prevention’s Child and Adolescent Immunization Schedule, the four other pediatricians at his practice told him the decision was unethical and effectively forced him out.
He opened an integrative pediatrics practice, where the number of parents opting out of vaccines steadily increased year after year. “The percentage of parents choosing not to vaccinate at all was just growing and growing,” Thomas said.
‘As more and more kids were unvaccinated, I had fewer and fewer sick visits’
Unvaccinated children “can and do get sick,” Tommey said. Thomas agreed. But he said the illness patterns in his practice surprised him.
“What I saw in my practice in the real world was, as more and more kids were unvaccinated, I had fewer and fewer sick visits,” Thomas said.
Tommey described how many parents of healthy, unvaccinated children still worry about worst-case scenarios — particularly illnesses like measles or whooping cough. They also worry that because they didn’t vaccinate their kids, doctors and hospital healthcare workers will be hostile when they bring their children in for treatment.
Many families steer clear of hospitals because of the “awful” way unvaccinated children are treated, she said. Thomas agreed, saying hospital staff often treat parents who don’t vaccinate “as if they’re a bad parent.”
Thomas encouraged parents to look beyond hospitals by seeking out like-minded pediatricians in their communities. He suggested asking friends for recommendations and calling medical practices directly, and asking, “We’re looking for a new pediatric practice and we want to know if you have any pediatricians that will support families who don’t vaccinate.”
Nine out of 10 offices will say no, but “that one out of 10 — that’s your spot,” Thomas said.
Whooping cough vaccine ‘is failing terribly’
Thomas said 2025 is shaping up to be one of the worst years for whooping cough in decades, but he rejected claims that unvaccinated families are to blame.
“It’s not because of the unvaxxed,” he said. “It is because the vaccine is failing terribly.”
According to Thomas, the DTaP and Tdap vaccines do not provide lasting protection. People who received those vaccines are “more likely to get whooping cough multiple times” than those who developed natural immunity, he said.
He also said severe outcomes are rare. Deaths typically average one to four per year nationwide, and they happen in both vaccinated and unvaccinated populations, he said. Deaths are “probably more likely to be in the vaccinated,” he said.
Public health agencies often label children “unvaccinated” simply for being behind on the schedule, regardless of prior doses, Tommey said.
There are effective treatments for whooping cough. Thomas cited vitamin C protocols discussed by Dr. Suzanne Humphries, author of “Dissolving Illusions: Disease, Vaccines, and The Forgotten History.”
Vaccinated caregivers put babies at ‘increased risk’
Tommey raised concerns about infant deaths following DTaP vaccination, calling the shot “so dangerous.”
Thomas agreed that the vaccine’s risk-benefit analysis is skewed. “You are far more likely to die from the vaccine … than you are from whooping cough,” he said.
He criticized messaging that highlights infant deaths from pertussis while failing to examine vaccine risks.
“You hear these stories that babies are dying from whooping cough,” Thomas said. “That sounds horrible. And if there’s a vaccine that could prevent that, why wouldn’t you do that? Right? That’s the logic. But then you’ve got to look at the flip side. Well, how safe is that vaccine?”
Thomas also challenged the idea that vaccinating adults protects infants, saying vaccinated caregivers are more likely to contract and transmit whooping cough. “The chances of your baby getting infected by a vaccinated person are much higher than they are from an unvaccinated person,” he said. “The data is clear.”
As for grandparents being urged to get boosters, Thomas said the risk outweighs any benefit. “Grannies will do anything for the grandkids, but there’s no benefit. It’s actually increased risk,” he said.
Giving kids Tylenol after a vaccine is ‘magnifying the toxicity’
Thomas sharply criticized the routine use of Tylenol in infants, particularly in conjunction with a vaccine.
He said pediatricians routinely advised parents to give Tylenol before and after shots — advice he now sees is harmful. Tylenol interferes with glutathione production, which he described as the body’s “major detox molecule.”
“You inject the toxins, and then you give a product that’s going to prevent that child, that baby, from getting rid of the toxins. So you’re magnifying the toxicity,” he said.
Thomas said he advises all families — vaccinating or not — to remove Tylenol from their homes.
He also emphasized that fever itself is not dangerous. “Fever is good. Fever means your immune system’s working,” he said.
He recommended intervening only when fevers rise above 103 or 104 degrees and children become lethargic or super irritable. He encourages parents to use cooling methods like wet washcloths instead of medication.
‘You’ve got a precious cargo … don’t vaccinate while you’re pregnant’
Thomas urged pregnant women to avoid all vaccines, including Tdap, flu, COVID-19 and RSV shots.
“It’s insane to activate the immune system while you’re pregnant,” he said, linking immune activation to miscarriage and long-term neurodevelopmental issues.
He encouraged mothers to trust their instincts. “You’ve got a precious cargo,” he said. “Don’t vaccinate while you’re pregnant.”
Risks outweigh benefits for Hep B, Hib and pneumococcal vaccines
Thomas dismissed the Hep B vaccine as unnecessary for children, saying it is potentially relevant only for people who are sexually active or using dirty needles. He described the vaccine as “very dangerous,” citing its aluminum content. He said he would never take it himself.
“The Hep B’s always been nonsense and ridiculous. It’s all toxicity, no benefit,” he said.
On DTaP, he said diphtheria is virtually nonexistent in the U.S., tetanus deaths in children are unheard of and pertussis risks are outweighed by vaccine harms. For severe wounds, he said targeted treatment — such as tetanus immune globulin — is sufficient.
“If tetanus was so dangerous,” millions of unvaccinated kids would be dying. “They’re not,” he added.
Thomas also said the Hib vaccine no longer targets the strains causing current illness. While Hib once caused severe disease, he said today’s cases are rare and largely unrelated to the vaccine strain.
Regarding pneumococcal vaccines, Thomas acknowledged that children can die from pneumococcal infections but argued that the vaccine poses a greater risk than the disease, which he said is treatable.
Speaking out against vaccines has cost Thomas financially. He estimated he forfeited “millions” by abandoning high-volume vaccination practices and ultimately giving up his license.
But he said the tradeoff brought peace. “What a blessing to know what you’re doing is right and to have no doubt about it,” he said.
Watch Dr. Paul Thomas on CHD.TV here:
The Centers for Disease Control and Prevention’s (CDC) vaccine advisory committee today heard from a vaccine injury lawyer who proposed the committee revisit the childhood vaccine schedule.
Attorney Aaron Siri told members of the Advisory Committee on Immunization Practices (ACIP) that the vaccines were recommended without sufficient data and that the expansion of the schedule coincided with a rise in chronic illness among U.S. children…
Charlie Kirk was brave and wise in every way. This man deserves a statue on every campus.
